Information and Communication Technologies (ICTs) can be cost-effectively and practicallyemployed to facilitate information delivery and knowledge sharing among farmers, extensionagents and other stakeholders. This paper presents aspects of the study that sought to examinethe challenges and prospects of infusing ICTs in extension for agricultural and ruraldevelopment in Ghana. The study used qualitative and quantitative procedures to collect thedata from 291 extension agents and ICTs service providers such as internet cafes, computertraining and business centers, computer firms, and information centers in the selected districtscapitals in Ghana. Means, percentages, frequencies, and standard deviation were generated todescribe the general trend of the data. The study revealed that extension agents have high andpositive demand for ICTs for extension. There is a prospect for involving private and publicinstitutional sources in extension delivery. The respondents have high knowledge about theadvantages of using ICTs which will probably enhance their application of the technologies inextension. However, extension agents need ICT training opportunities, infrastructure, financialresources and technical backstopping to enhance the use of ICTs in extension. The studyrecommends a systems approach involving major stakeholders such as training institutions,Internet service providers, research institutions, farmers, policy makers to collaborate in the useof ICTs for extension.