A recent USAID report showed that, although the health status of Ghanaians has improved inrecent decades, many health challenges still remain. Examples include: a) the maternal deathrate which in some parts of Ghana, is 800 per 100000 live births; b) malaria which is the basisfor 40% of outpatient visits and 25% of the mortality of children under six years of age; c)inadequate and insufficient prevention efforts, poor nutrition and lack of early and effectivetreatment. In addition, about 400,000 Ghanaians live with HIV/AIDS with over 50,000 AIDSrelated orphans. Moreover, access to quality health services at the community level presents amajor constraint for providing quality health care to community people. With respect toagriculture, despite the general improvement in cereal crops and other basic staple food crops,agricultural production fluctuates immensely from year to year and from region to region. Inthis paper the associations among gender, educational and health disparities and type of placeof residence are investigated. Case studies of successful health and agricultural interventionsthat took place in Ghana in past are explored. The success stories are brought into perspectivewith the current health and agricultural challenges facing Ghana and possible solutions areexplored.